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KMID : 0616120170480020097
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 2 p.97 ~ p.107
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Toward a More Complete Understanding of the Effects of Korean Ginseng (Panax ginseng) on Blood Pressure
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Nam Ki-Yeul
Yang Byung-Wook
Shin Wang-Soo
Park Jong-Dae
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Abstract
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There is no doubt that the effect of ginseng on blood pressure could be different depending upon the type of ginseng employed for the experiment and methodology, thereby can exert bilateral modulatory activity on blood pressure. It has been reported that ginseng induced no significant change in blood pressure in those subjects with normal blood pressure, but had a normalizing effect on the subjects with abnormal blood pressure. Especially, experimental evidence indicates that ginsenoside Rg3, a major component of red ginseng, has been found to lower blood pressure, which is mediated by release of endotheliumderived NO, enhancing the accumulation of cGMP in the rat aorta. This clinical results further support the beneficial effect of Korean ginseng on blood pressure elucidated by animal experiment. As expected, a multicentric non-controlled clinical study shows that the effect of ginseng consumption has been found to normalize blood pressure in hypertensive or hypotensive individuals as compared to virtually no effect in normotensives. In addition, ginseng has been known to exhibit blood pressure decreased with no significant side effect and deteriorated QOL during the combination therapy of ginseng and anti-hypertensive drugs. This review provides a comprehensive overview on the effects of Korean ginseng on blood pressure.
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KEYWORD
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Panax ginseng, Ginsenosides, Blood pressure, Biological activities, Safety, Mechanisms
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